Caloric Restriction Could Mean a 20% Extension in Lifespan

Sinclair and several other prominent gerontologists are presently seeking human therapies based on the long-standing observation that lifelong restriction of caloric intake considerably extends both the healthy and total life span of nearly all species in which it has been tried, including rodents and dogs. Drugs that elicit the gene expression changes that result from caloric restriction might, these workers assert, extend human life span by something approaching the same proportion as seen ...

 Research Domain Criteria (RDoC)

The goal of this new manual, as with all previous editions, is to provide a common language for describing psychopathology. While DSM has been described as a “Bible” for the field, it is, at best, a dictionary, creating a set of labels and defining each. The strength of each of the editions of DSM has been “reliability” – each edition has ensured that clinicians use the same terms in the same ways. The weakness is its lack of validity. Unlike our definitions of ischemic heart diseas...

 Aristotle as the First Scientist

Aristotle repeatedly pointed out that his predecessors' work and conclusions were often marred by insufficient observation. He himself, after a remarkable analysis of the reproduction of bees, states that he cannot arrive at certain conclusions because "the facts have not yet been sufficiently ascertained. And if at any future time they are ascertained, then credence must be given to the direct evidence rather than to the theories; and to the theories also, provided that the results which the...

 The von Neumann Model for Computing Machines

At the highest level, the major hardware components of most boards can be classifi ed into fi ve major categories: Central processing unit (CPU). The master processor. Memory. Where the system’s software is stored. Input device(s). Input slave processors and relative electrical components. Output device(s). Output slave processors and relative electrical components. Data pathway(s)/bus(es). Interconnects the other components, providing a “highway” for data to travel on from one compone...